See for a full list of publications from the lab here
Giraud M, Yun DH, Munting LP, Chung K, Bacskai BJ, Greenberg SM, Frosch MP, Goriely A, van Veluw SJ, Lorthois S. CAA-related enlarged perivascular spaces are associated with abnormal angioarchitecture in human brain tissue: A key role for white matter atrophy? J Cereb Blood Flow Metab. 2025 Sep 8:271678X251369256.
Perosa V, Oltmer J, Bax F, van den Berg ML, Auger CA, Rotta J, Perbet R, Augustinack J, Frosch MP, Connors T, Greenberg SM, Hyman BT, van Veluw SJ. Relationship between cerebral small vessel disease and proteinopathies in the medial temporal lobe. Acta Neuropathol Commun. 2025 Jul 16;13(1):156.
Kozberg MG, Munting LP, Hanlin LH, Auger CA, van den Berg ML, Denis de Senneville B, Hirschler L, Warnking JM, Barbier EL, Farrar CT, Greenberg SM, Bacskai BJ, van Veluw SJ. Vasomotion loss precedes impaired cerebrovascular reactivity and microbleeds in cerebral amyloid angiopathy. Brain Commun. 2025 May 14;7(3):fcaf186.
Bonnar O, Eyre B, van Veluw SJ. Perivascular brain clearance as a therapeutic target in cerebral amyloid angiopathy and Alzheimer's disease. Neurotherapeutics. 2025 Apr;22(3):e00535.
Greenberg SM, Bax F, van Veluw SJ. Amyloid-related imaging abnormalities: manifestations, metrics and mechanisms. Nat Rev Neurol. 2025 Apr;21(4):193-203.
Makkinejad N, Zanon Zotin MC, van den Brink H, Auger CA, Vom Eigen KA, Iglesias JE, Greenberg SM, Perosa V, van Veluw SJ. Neuropathological Correlates of White Matter Hyperintensities in Cerebral Amyloid Angiopathy. J Am Heart Assoc. 2024 Nov 19;13(22):e035744.
van Veluw SJ, Benveniste H, Bakker ENTP, Carare RO, Greenberg SM, Iliff JJ, Lorthois S, Van Nostrand WE, Petzold GC, Shih AY, van Osch MJP. Is CAA a perivascular brain clearance disease? A discussion of the evidence to date and outlook for future studies. Cell Mol Life Sci. 2024 May 27;81(1):239.
Koemans EA, Perosa V, Freeze WM, Lee H, Kozberg MG, Coughlan GT, Buckley RF, Wermer MJ, Greenberg SM, van Veluw SJ. Sex differences in histopathological markers of cerebral amyloid angiopathy and related hemorrhage. Int J Stroke. 2024 Oct;19(8):947-956.
van Veluw SJ, Young MJ. Ethical considerations for the use of anti-amyloid immunotherapy in patients with early Alzheimer's disease. Alzheimers Dement. 2024 May;20(5):3664-3665.
van Veluw SJ, Benveniste H, van Osch MJP; Leducq Foundation Transatlantic Network of Excellence on Brain Clearance. A translational approach towards understanding brain waste clearance in cerebral amyloid angiopathy. Eur Heart J. 2024 May 7;45(17):1500-1502.
Greenberg SM, van Veluw SJ. Cerebral Amyloid Angiopathy. Stroke. 2024 May;55(5):1409-1411.
Zanon Zotin MC, Makkinejad N, Schneider JA, Arfanakis K, Charidimou A, Greenberg SM, van Veluw SJ. Sensitivity and Specificity of the Boston Criteria Version 2.0 for the Diagnosis of Cerebral Amyloid Angiopathy in a Community-Based Sample. Neurology. 2024 Jan 9;102(1):e207940.
Auger CA, Perosa V, Greenberg SM, van Veluw SJ, Kozberg MG. Cortical superficial siderosis is associated with reactive astrogliosis in cerebral amyloid angiopathy. J Neuroinflammation. 2023 Aug 27;20(1):195.
Perosa V, Auger CA, Zanon Zotin MC, Oltmer J, Frosch MP, Viswanathan A, Greenberg SM, van Veluw SJ. Histopathological Correlates of Lobar Microbleeds in False-Positive Cerebral Amyloid Angiopathy Cases. Ann Neurol. 2023 Nov;94(5):856-870.
Koemans EA, Chhatwal JP, van Veluw SJ, van Etten ES, van Osch MJP, van Walderveen MAA, Sohrabi HR, Kozberg MG, Shirzadi Z, Terwindt GM, van Buchem MA, Smith EE, Werring DJ, Martins RN, Wermer MJH, Greenberg SM. Progression of cerebral amyloid angiopathy: a pathophysiological framework. Lancet Neurol. 2023 Jul;22(7):632-642.
Munting LP, Bonnar O, Kozberg MG, Auger CA, Hirschler L, Hou SS, Greenberg SM, Bacskai BJ, van Veluw SJ. Spontaneous vasomotion propagates along pial arterioles in the awake mouse brain like stimulus-evoked vascular reactivity. J Cereb Blood Flow Metab. 2023 Oct;43(10):1752-1763.
Kozberg MG, Yi I, Freeze WM, Auger CA, Scherlek AA, Greenberg SM, van Veluw SJ. Blood-brain barrier leakage and perivascular inflammation in cerebral amyloid angiopathy. Brain Commun. 2022 Sep 26;4(5):fcac245.
Freeze WM, Zanon Zotin MC, Scherlek AA, Perosa V, Auger CA, Warren AD, van der Weerd L, Schoemaker D, Horn MJ, Gurol ME, Gokcal E, Bacskai BJ, Viswanathan A, Greenberg SM, Reijmer YD, van Veluw SJ. Corpus callosum lesions are associated with worse cognitive performance in cerebral amyloid angiopathy. Brain Commun. 2022 Apr 26;4(3):fcac105.
Scherlek AA, Kozberg MG, Nicoll JAR, Perosa V, Freeze WM, van der Weerd L, Bacskai BJ, Greenberg SM, Frosch MP, Boche D, van Veluw SJ. Histopathological correlates of haemorrhagic lesions on ex vivo magnetic resonance imaging in immunized Alzheimer's disease cases. Brain Commun. 2022 Feb 3;4(1):fcac021.
van Veluw SJ, Arfanakis K, Schneider JA. Neuropathology of Vascular Brain Health: Insights From Ex Vivo Magnetic Resonance Imaging-Histopathology Studies in Cerebral Small Vessel Disease. Stroke. 2022 Feb;53(2):404-415.
Perosa V, Oltmer J, Munting LP, Freeze WM, Auger CA, Scherlek AA, van der Kouwe AJ, Iglesias JE, Atzeni A, Bacskai BJ, Viswanathan A, Frosch MP, Greenberg SM, van Veluw SJ. Perivascular space dilation is associated with vascular amyloid-β accumulation in the overlying cortex. Acta Neuropathol. 2022 Mar;143(3):331-348.
Perosa V, Scherlek AA, Kozberg MG, Smith L, Westerling-Bui T, Auger CA, Vasylechko S, Greenberg SM, van Veluw SJ. Deep learning assisted quantitative assessment of histopathological markers of Alzheimer's disease and cerebral amyloid angiopathy. Acta Neuropathol Commun. 2021 Aug 21;9(1):141.
Kozberg MG, Perosa V, Gurol ME, van Veluw SJ. A practical approach to the management of cerebral amyloid angiopathy. Int J Stroke. 2021 Jun;16(4):356-369.
van Veluw SJ, Frosch MP, Scherlek AA, Lee D, Greenberg SM, Bacskai BJ. In vivo characterization of spontaneous microhemorrhage formation in mice with cerebral amyloid angiopathy. J Cereb Blood Flow Metab. 2021 Jan;41(1):82-91.
Freeze WM, van der Thiel M, de Bresser J, Klijn CJM, van Etten ES, Jansen JFA, van der Weerd L, Jacobs HIL, Backes WH, van Veluw SJ. CSF enhancement on post-contrast fluid-attenuated inversion recovery images; a systematic review. Neuroimage Clin. 2020;28:102456.
Charidimou A, Perosa V, Frosch MP, Scherlek AA, Greenberg SM, van Veluw SJ. Neuropathological correlates of cortical superficial siderosis in cerebral amyloid angiopathy. Brain. 2020 Dec 5;143(11):3343-3351.
Kozberg MG, van Veluw SJ, Frosch MP, Greenberg SM. Hereditary cerebral amyloid angiopathy, Piedmont-type mutation. Neurol Genet. 2020 Mar 13;6(2):e411.
Ter Telgte A, Scherlek AA, Reijmer YD, van der Kouwe AJ, van Harten T, Duering M, Bacskai BJ, de Leeuw FE, Frosch MP, Greenberg SM, van Veluw SJ. Histopathology of diffusion-weighted imaging-positive lesions in cerebral amyloid angiopathy. Acta Neuropathol. 2020 May;139(5):799-812.
Greenberg SM, Bacskai BJ, Hernandez-Guillamon M, Pruzin J, Sperling R, van Veluw SJ. Cerebral amyloid angiopathy and Alzheimer disease - one peptide, two pathways. Nat Rev Neurol. 2020 Jan;16(1):30-42.
van Veluw SJ, Hou SS, Calvo-Rodriguez M, Arbel-Ornath M, Snyder AC, Frosch MP, Greenberg SM, Bacskai BJ. Vasomotion as a Driving Force for Paravascular Clearance in the Awake Mouse Brain. Neuron. 2020 Feb 5;105(3):549-561.e5.
van Veluw SJ, Scherlek AA, Freeze WM, Ter Telgte A, van der Kouwe AJ, Bacskai BJ, Frosch MP, Greenberg SM. Different microvascular alterations underlie microbleeds and microinfarcts. Ann Neurol. 2019 Aug;86(2):279-292.
van Veluw SJ, Reijmer YD, van der Kouwe AJ, Charidimou A, Riley GA, Leemans A, Bacskai BJ, Frosch MP, Viswanathan A, Greenberg SM. Histopathology of diffusion imaging abnormalities in cerebral amyloid angiopathy. Neurology. 2019 Feb 26;92(9):e933-e943.
Freeze WM, Bacskai BJ, Frosch MP, Jacobs HIL, Backes WH, Greenberg SM, van Veluw SJ. Blood-Brain Barrier Leakage and Microvascular Lesions in Cerebral Amyloid Angiopathy. Stroke. 2019 Feb;50(2):328-335.
Shih AY, Hyacinth HI, Hartmann DA, van Veluw SJ. Rodent Models of Cerebral Microinfarct and Microhemorrhage. Stroke. 2018 Mar;49(3):803-810.
van Veluw SJ, Lauer A, Charidimou A, Bounemia N, Xiong L, Boulouis G, Fotiadis P, Ayres A, Gurol ME, Viswanathan A, Greenberg SM, Vernooij MW. Evolution of DWI lesions in cerebral amyloid angiopathy: Evidence for ischemia. Neurology. 2017 Nov 21;89(21):2136-2142.
van Veluw SJ, Shih AY, Smith EE, Chen C, Schneider JA, Wardlaw JM, Greenberg SM, Biessels GJ. Detection, risk factors, and functional consequences of cerebral microinfarcts. Lancet Neurol. 2017 Sep;16(9):730-740.
van Veluw SJ, Kuijf HJ, Charidimou A, Viswanathan A, Biessels GJ, Rozemuller AJ, Frosch MP, Greenberg SM. Reduced vascular amyloid burden at microhemorrhage sites in cerebral amyloid angiopathy. Acta Neuropathol. 2017 Mar;133(3):409-415.
van Veluw SJ, Charidimou A, van der Kouwe AJ, Lauer A, Reijmer YD, Costantino I, Gurol ME, Biessels GJ, Frosch MP, Viswanathan A, Greenberg SM. Microbleed and microinfarct detection in amyloid angiopathy: a high-resolution MRI-histopathology study. Brain. 2016 Dec;139(Pt 12):3151-3162.
van Veluw SJ, Biessels GJ, Klijn CJ, Rozemuller AJ. Heterogeneous histopathology of cortical microbleeds in cerebral amyloid angiopathy. Neurology. 2016 Mar 1;86(9):867-71.
van Veluw SJ, Biessels GJ, Bouvy WH, Spliet WG, Zwanenburg JJ, Luijten PR, Macklin EA, Rozemuller AJ, Gurol ME, Greenberg SM, Viswanathan A, Martinez-Ramirez S. Cerebral amyloid angiopathy severity is linked to dilation of juxtacortical perivascular spaces. J Cereb Blood Flow Metab. 2016 Mar;36(3):576-80.
Reijmer YD, van Veluw SJ, Greenberg SM. Ischemic brain injury in cerebral amyloid angiopathy. J Cereb Blood Flow Metab. 2016 Jan;36(1):40-54.
van Veluw SJ, Biessels GJ, Luijten PR, Zwanenburg JJ. Assessing Cortical Cerebral Microinfarcts on High Resolution MR Images. J Vis Exp. 2015 Nov 20;(105):53125.
van Veluw SJ, Hilal S, Kuijf HJ, Ikram MK, Xin X, Yeow TB, Venketasubramanian N, Biessels GJ, Chen C. Cortical microinfarcts on 3T MRI: Clinical correlates in memory-clinic patients. Alzheimers Dement. 2015 Dec;11(12):1500-1509.
van Veluw SJ, Zwanenburg JJ, Rozemuller AJ, Luijten PR, Spliet WG, Biessels GJ. The spectrum of MR detectable cortical microinfarcts: a classification study with 7-tesla postmortem MRI and histopathology. J Cereb Blood Flow Metab. 2015 Mar 31;35(4):676-83.
van Veluw SJ, Fracasso A, Visser F, Spliet WG, Luijten PR, Biessels GJ, Zwanenburg JJ. FLAIR images at 7 Tesla MRI highlight the ependyma and the outer layers of the cerebral cortex. Neuroimage. 2015 Jan 1;104:100-9.
van Veluw SJ, Jolink WM, Hendrikse J, Geerlings MI, Luijten PR, Biessels GJ, Klijn CJ. Cortical microinfarcts on 7T MRI in patients with spontaneous intracerebral hemorrhage. J Cereb Blood Flow Metab. 2014 Jul;34(7):1104-6.
van Veluw SJ, Heringa SM, Kuijf HJ, Koek HL, Luijten PR, Biessels GJ; Utrecht Vascular Cognitive Impairment study group. Cerebral cortical microinfarcts at 7Tesla MRI in patients with early Alzheimer's disease. J Alzheimers Dis. 2014;39(1):163-7.
van Veluw SJ, Wisse LE, Kuijf HJ, Spliet WG, Hendrikse J, Luijten PR, Geerlings MI, Biessels GJ. Hippocampal T2 hyperintensities on 7 Tesla MRI. Neuroimage Clin. 2013 Aug 17;3:196-201.
van Veluw SJ, Zwanenburg JJ, Engelen-Lee J, Spliet WG, Hendrikse J, Luijten PR, Biessels GJ. In vivo detection of cerebral cortical microinfarcts with high-resolution 7T MRI. J Cereb Blood Flow Metab. 2013 Mar;33(3):322-9.